WAY-317,538

WAY-317,538

Systematic (IUPAC) name
5-morpholin-4-yl-pentanoic acid (4-pyridin-3-yl-phenyl)-amide
Clinical data
Legal status	Legal
Identifiers
ChemSpider	24663034 N
ChEMBL	CHEMBL1084615 N
Chemical data
Formula	C20H25N3O2
Molecular mass	339.430
SMILES C3COCCN3CCCCC(=O)Nc1ccc(cc1)-c2cccnc2
InChI InChI=1S/C20H25N3O2/c24-20(5-1-2-11-23-12-14-25-15-13-23)22-19-8-6-17(7-9-19)18-4-3-10-21-16-18/h3-4,6-10,16H,1-2,5,11-15H2,(H,22,24) N Key:XCHIZTUBUXZESJ-UHFFFAOYSA-N N
NY (what is this?)  (verify)

WAY-317,538 (SEN-12333) is a drug that acts as a potent and selective full agonist for the α7 subtype of neural nicotinic acetylcholine receptors. It was not the most potent compound in the series, but was selected for further development on the basis of its high selectivity over related receptors, ease of synthesis, and good in vivo properties including high oral bioavailability and good brain penetration. It has nootropic and neuroprotective effects in animal studies, and is being investigated as a potential treatment for neurodegenerative and neurocognitive conditions including Alzheimer's disease and schizophrenia.