Litoxetine

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Litoxetine (SL 81-0385) is an antidepressant which was under clinical development for the treatment of depression in the early 1990s.[1] It acts as a serotonin reuptake inhibitor and 5-HT3 receptor antagonist. It has prominent antiemetic properties, and unlike the selective serotonin reuptake inhibitors (SSRIs), it was shown to have a negligible incidence of nausea and emesis.[2] Development of litoxetine for medicinal use was apparently halted in the late 1990s.

References

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