Periciazine

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Periciazine
Periciazine.svg
Systematic (IUPAC) name
10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile
Clinical data
Pregnancy
category
  • AU: C
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • UK: POM (Prescription only)
  • ℞ (Prescription only)
Routes of
administration		 Oral
Pharmacokinetic data
Metabolism Hepatic (mostly via conjugation)[1]
Biological half-life 12 h[1]
Excretion Renal[1]
Identifiers
CAS Number 2622-26-6 YesY
ATC code N05AC01 (WHO)
PubChem CID: 4747
DrugBank DB01608 N
ChemSpider 4585 N
UNII 3405M6FD73 YesY
KEGG D01485 YesY
ChEBI CHEBI:31981 N
ChEMBL CHEMBL251940 N
Chemical data
Formula C21H23N3OS
Molecular mass 365.49 g/mol
  • C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
  • InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2 N
  • Key:LUALIOATIOESLM-UHFFFAOYSA-N N
 NYesY (what is this?)  (verify)

Periciazine (INN), also known as pericyazine (BAN) or propericiazine, is a drug that belongs to the phenothiazine class of typical antipsychotics.

Pericyazine is not approved for sale in the United States. It is commonly sold in Canada under the tradename Neuleptil and in United Kingdom and Australia under the tradename Neulactil.[2]

Medical Uses

The primary uses of pericyazine include in the short-term treatment of severe anxiety or tension and in the maintenance treatment of psychotic disorders such as schizophrenia. There is insufficient evidence to determine whether periciazine is more or less effective than other antipsychotics.[1][3]

Periciazine has also been studied in the treatment of opioid dependence.[4]

Adverse effects

Pericyazine is a rather sedating and anticholinergic antipsychotic, and despite being classed with the typical antipsychotics, its risk of extrapyramidal side effects is comparatively low.[5] It has a relatively high risk of causing hyperprolactinaemia and a moderate risk of causing weight gain and orthostatic hypotension.[5]

References

  1. ↑ 1.0 1.1 1.2 1.3 Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Leucht S, Helfer B, Hartung B. Perazine for schizophrenia. Cochrane Database Syst Rev. 2014 Jan 15;1:CD002832. Review. doi:10.1002/14651858.CD002832.pub3 PMID 24425538
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ 5.0 5.1 Lua error in package.lua at line 80: module 'strict' not found.

External links


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