5,7-Dihydroxytryptamine

5,7-Dihydroxytryptamine

Names
IUPAC name 3-(2-aminoethyl)-1H-indole-5,7-diol
Other names 5,7-Dihydroxytryptamine
Identifiers
CAS Number	31363-74-3 N
ChEMBL	ChEMBL26726 Y
ChemSpider	32913 Y
Jmol 3D model	Interactive image
PubChem	35781
InChI InChI=1S/C10H12N2O2/c11-2-1-6-5-12-10-8(6)3-7(13)4-9(10)14/h3-5,12-14H,1-2,11H2 Y Key: LXWHQTNFZDTKBH-UHFFFAOYSA-N Y InChI=1/C10H12N2O2/c11-2-1-6-5-12-10-8(6)3-7(13)4-9(10)14/h3-5,12-14H,1-2,11H2 Key: LXWHQTNFZDTKBH-UHFFFAOYAC
SMILES Oc1cc2c(c(O)c1)ncc2CCN
Properties
Chemical formula	C10H12N2O2
Molar mass	192.214 g/mol
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

5,7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin used in scientific research to decrease concentrations of serotonin in the brain. The mechanism behind this effect isn't well-understood, but many believe (without clear substantiation) that it selectively kills serotonergic neurons, in a similar way that 6-hydroxydopamine (6-OHDA) is used to kill dopaminergic cells. What is known is that this compound is in fact not selective in depleting serotonin content, but also depletes norepinephrine. To selectively deplete serotonin stores, it is commonly administered in conjunction with desmethylimiprimine (desipramine)[3], which inhibits the norepinephrine transporter.

See also

• 6-Hydroxydopamine (6-OHDA)
• para-Chlorophenylalanine (PCPA)

References

3. Martin-Iverson, M.T., Leclere, J.F. and Fibiger, H.C., Cholinergic-dopaminergic interactions and the mechanisms of action of antidepressants, European Journal of Pharmacology, 94 (1983) 193-201.