Brian Kobilka

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Brian Kobilka
Brian Kobilka (649437151).jpg
Born Brian Kent Kobilka
(1955-05-30) May 30, 1955 (age 68)
Little Falls, Minnesota, USA
Nationality American
Fields Crystallography
Institutions Stanford University, Duke University
Alma mater University of Minnesota Duluth, Yale University
Academic advisors Robert Lefkowitz
Notable awards Nobel Prize in Chemistry (2012)
Brian Kobilka in Stockholm 2012

Brian Kent Kobilka (born May 30, 1955)[1] is an American physiologist and a recipient of the 2012 Nobel Prize in Chemistry with Robert Lefkowitz for discoveries that reveal the inner workings of an important family G protein-coupled receptors. He is currently a professor in the department of Molecular and Cellular Physiology at Stanford University School of Medicine. He is also the co-founder of ConfometRx, a biotechnology company focusing on G protein-coupled receptors. He was named a member of the National Academy of Sciences in 2011.

Early life

Kobilka, a Roman Catholic, attended St. Mary's Grade School in Little Falls, Minnesota, a part of the Roman Catholic Diocese of Saint Cloud.[2] He then Graduated from Little Falls High School. He received a Bachelor’s Degree in Biology and Chemistry from the University of Minnesota Duluth, and earned his M.D., cum laude, from Yale University School of Medicine. Following the completion of his residency in internal medicine at Barnes-Jewish Hospital in St. Louis, Missouri, Kobilka worked in research as a postdoctoral fellow under Robert Lefkowitz at Duke University, where he started work on cloning the β2-adrenergic receptor. Kobilka moved to Stanford in 1989.[3] He was a Howard Hughes Medical Institute (HHMI) investigator from 1987-2003.[4]

Research

Kobilka is best known for his research on the structure and activity of G protein-coupled receptors (GPCRs); in particular, work from Kobilka's laboratory determined the molecular structure of the β2-adrenergic receptor.[5][6][7][8] This work has been highly cited by other scientists because GPCRs are important targets for pharmaceutical therapeutics, but notoriously difficult to work with in X-ray crystallography.[9] Before, rhodopsin was the only G-protein coupled receptor where the structure had been determined at high resolution. The β2-adrenergic receptor structure was soon followed by the determination of the molecular structure of several other G-protein coupled receptors.[10]

Kobilka is the 1994 recipient of the American Society for Pharmacology and Experimental Therapeutics John J. Abel Award in Pharmacology.[11] His GPCR structure work was named "runner-up" for the 2007 "Breakthrough of the Year" award from Science.[12] The work was, in part, supported by Kobilka's 2004 Javits Neuroscience Investigator Award[13] from the National Institute of Neurological Disorders and Stroke.[14] He received the 2012 Nobel Prize in Chemistry with Robert Lefkowitz for his work on G protein-coupled receptors.[15][16]

Personal life

Kobilka is from Little Falls in central Minnesota. Both his grandfather Felix J. Kobilka (1893-1991) and his father Franklyn A. Kobilka (1921-2004) were bakers and natives of Little Falls, Minnesota.[17][18][19] Kobilka's grandmother, Isabelle Susan Kobilka (née Medved, 1891-1980), belonged to the Medved and Kiewel families of Prussian immigrants, who from 1888 owned the historical Kiewel brewery in Little Falls. His mother is Betty L. Kobilka (née Faust, b. 1930).

Kobilka met his wife Tong Sun Thian, a Malaysian-Chinese woman,[20] at the University of Minnesota Duluth. They have two children, Jason and Megan Kobilka.[17][21]

References

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  19. Social Security Death Index
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Publications

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External links

Awards
Preceded by Nobel Prize in Chemistry laureate
2012
With: Robert Lefkowitz
Succeeded by
Michael Levitt
Martin Karplus
Arieh Warshel